| 英文名稱 | Rabbit DOK4 Polyclonal Antibody |
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| 應(yīng)用2 | WB IHC IF |
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| 克隆類型2 | Polyclonal Antibody |
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| 別名 | IRS-5;IRS5
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| 應(yīng)用 | WB,IHC,IF |
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| 稀釋比例 | WB1:500-1:2000 IHC1:50-1:200 IF1:50-1:200 |
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| 交叉反應(yīng) | Human Mouse Rat |
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| 蛋白分子量 | 37kDa |
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| Gene ID | 55715 |
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| 保存 | Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment. |
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| 儲(chǔ)存液 | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
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| 亞型 | IgG |
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| 免疫原 | Recombinant Protein of human DOK4 |
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| 性狀 | Lyophilized or Liquid |
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| Swiss Prot | Q8TEW6 |
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| 來(lái)源 | Rabbit |
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| 背景資料 | The downstream of kinase family (Dok-1-7) are members of a class of docking proteins that interact with receptor tyrosine kinases and, via this interaction, mediate biological responses within the body. Dok-4 (Downstream of kinase-4) is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.
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